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Archive
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2017
- January
- February
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March
- Professor Robert Stewart awarded ‘Collaborate to Innovate’ project
- NIHR Maudsley BRC researchers receive Senior Investigator awards
- Research blog: Using social media to recognise mental health conditions
- Department of Health Chief Scientific Adviser Chris Whitty visits Maudsley BRC
- NIHR Maudsley BRC commences five-year research programme
- IMPARTS Seminar Learning from experience
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April
- New research highlights higher hospitalisation rates in people with intellectual disabilities
- Digital Technology for Mental Health: Asking the right questions
- NIHR Maudsley BRC holiday closure Easter 2017
- Maudsley becomes London’s Global Digital Exemplar
- CRIS blog: An online risk calculator to identify candidates for early intervention services
- May
- June
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July
- NIHR Maudsley BRC researcher wins award to understand suicide warning signs in children
- Who are the NIHR? #WeAreNIHR
- Brain stimulation may improve cognitive performance in people with schizophrenia
- Risk for bipolar disorder associated with faster ageing
- Omega-3 fatty acids improve symptoms in children and adolescents with ADHD
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August
- South London and Maudsley tops NIHR league table for number of active research studies
- Connecting care homes with research
- Research blog: Using advanced search technologies to help manage infectious disease outbreaks
- A&E attendance for people with dementia is common and increasing
- Event: Seminar on dementia art project "Beyond Memories"
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November
- Professor Oliver Howes receives Royal College of Psychiatrists Award
- First network analysis of patient flow in two UK hospitals published
- Honorary Degree for Professor Dame Til Wykes
- Concentrated naloxone nasal spray as good as injection
- Professor Matthew Hotopf appointed Vice Dean
- Potential for machine learning to predict unknown adverse drug reactions
- Complications at birth associated with lasting chemical changes in the brain
- Study examines opiate-dependent patient deaths
- NIHR Lectureship awarded
- Treatment cuts migraine days by half
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2016
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March
- CRIS Blog: Serious Mental Illness and Pregnancy
- Kings world-class contribution to understanding of clozapine
- Research blog: PROMPT project reveals complex profile of people using psychological therapy services
- Tony David John Toulmin Lecture
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April
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May
- Dermatology clinic psychology screening project shortlisted for BMJ Awards
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- BMJ Award for team who are incorporating mental health service into dermatology clinic
- Research blog systematic biases in death certification
- Event launch of new collaboration for digital innovation in mental health
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- Research blog International Clinical Trials Day
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June
- Blood test to personalise depression treatment for the first time
- Centre for Translational Informatics launches
- Professor John Strang receives Knighthood
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- Mental health hackday - your help needed
- Research blog Trialling an online tool to help women make decisions about antidepressants in pregnancy
- Data linkage group your help needed
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July
- CRIS blog: Investigating the impact of antipsychotic medications used to treat people with serious mental illness
- Research blog Maudsley BRC part of winning team at NIHR training camp
- Neuroimaging theme research funding
- NIHR Maudsley BRC announces 2016 Youth Awards winners
- Event Illusions A window to your brain
- August
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September
- Matthew Hotopf wins prestigious Katon Research Award
- IMPARTS shortlisted for HSJ award
- NIHR Maudsley BRC receives £66m new investment from government
- NIHR Maudsley BRC researchers win prestigious awards
- Event NIHR i4i Programme Mental Health Challenge Awards Launch
- Genetic tests could help predict which psychosis patients will develop schizophrenia
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October
- BRC leaders receive academic promotions
- Event No Exchange, Same Pain, No Gain - Risk-Reward of Wearable Healthcare Disclosure for Receiving Pain Treatment
- C4C recruits 10k
- Research blog: How fatty clues in the blood are improving our understanding of Alzheimer’s disease
- Early intervention shows promising long-term reduction in severity of autism symptoms
- Bringing mental health education to a classroom of 300
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November
- South London and Maudsley rated top mental health trust for recruiting patients to clinical studies
- Mental Health & Technology: Ideas Generation Workshop
- NIHR i4i mental health challenge launch
- UK Government announces £4m investment in NIHR Wellcome Trust King’s Clinical Research Facility
- NIHR Maudsley BRC PhD student wins International Society for the History of Neurosciences book prize
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December
- Event Suicide detection and prevention using mobile technology, social media and informatics
- Event Misconceptions and Reconceptualisations in Digital Mental Health
- Research blog: Defining treatment resistance in schizophrenia
- Mental health needs of baby boomers covered in new report from England’s Chief Medical Officer
- 2015
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2018
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April
- UK Biobank mental health study
- CRIS blog: Using CRIS to evaluate mental health diagnoses in routine national statistics
- Engaging in physical activity decreases people’s chance of developing depression
- Unprecedented study identifies 44 genetic risk factors for major depression
- New research: Hospitals often missing dementia despite prior diagnosis
- May
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November
- 2018 Takeover Challenge
- CRIS blog: The future of psychiatry research
- CRIS blog: Do long-term prescriptions of multiple antipsychotics contribute to the reduced life expectancy of patients with serious mental illness?
- Improving dementia care and treatment saves thousands of pounds in care homes
- New service in south London reduces hospital readmissions for people with bipolar disorder
- Ten BRC researchers and academics among most cited in the world
- Students 'take over' the BRC
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December
- Computers can ‘spot the difference’ between healthy brains and the brains of people with Dissociative Identity Disorder
- Service User Advisory Group for 12-16-year-olds
- New Clinical Disorders and Health Behaviours cluster lead announced
- Blog: The SLG Arts Assassins collaborate with the BRC
- Professor Matthew Hotopf receives CBE at Buckingham Palace
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2019
- January
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February
- Eating a healthy diet can ease symptoms of depression
- Pathfinders and the public
- NIHR Maudsley BRC researchers host dementia discussion in collaboration with South London Theatre
- Could intranasal oxytocin be used to treat people at clinically high risk of psychosis?
- CRIS blog: Using data on hospital episodes to look at the physical health of people with personality disorders
CRIS blog: Investigating the impact of antipsychotic medications used to treat people with serious mental illness
Richard Hayes is a Senior Lecturer at King’s College London’s Department of Psychological Medicine. He leads a team of researchers who use the Clinical Record Interactive Search (CRIS) database (an anonymised mental health care database) to investigate the impact of medications used on mental health care on people’s mental and physical health, particularly focusing on antipsychotics prescribed to people with serious mental illness.
Serious mental illnesses, including schizophrenia, schizoaffective disorder and bipolar affective disorder are debilitating mental disorders which have a substantial impact on people’s lives. People with serious mental illnesses live with marked health disparities, resulting from stigma, adverse lifestyles as well as the direct consequences of their mental illness.
Our research has estimated that individuals with serious mental illnesses die between 10-15 years earlier than the general population, comparable to the impact of smoking, diabetes and obesity. Underlying factors however remain unclear. The higher mortality risk is only partially explained by suicide, accidents or violence, and natural causes remain an important component including death from coronary heart disease and stroke, which are in turn not fully explained by poor lifestyle choices such as smoking.
Despite improving healthcare, serious mental illnesses continue to have a chronic relapsing course and marked impairment in a high proportion of those diagnosed with these disorders. Antipsychotic medications have been a mainstay of treatment for serious mental illnesses since the 1950s and are used to manage psychotic symptoms, including hallucinations and delusions. The effectiveness of antipsychotics currently used clinically has been assessed in numerous randomized controlled trials, however, a number of adverse effects have been reported, including, weight gain, diabetes, cardiovascular diseases, lowered white blood cell count (agranulocytosis).
Although randomized controlled trials are recognized as essential for investigating whether medications are effective, these trials are usually conducted under idealized circumstances, they tend to look at in restricted groups of people and monitor them over relatively short periods of time. In practice, antipsychotics are used in a variety of ways that are not within the scope of most randomized controlled trials. For example, prescribing more than one antipsychotic at the same time occurs. Moreover, clinicians may switch medications or increase the dose in pursuit of an optimal therapeutic effect.
Clozapine is unique among antipsychotics in having proven efficacy in individuals who have been unresponsive to other treatments. However, for a variety of reasons, psychiatrists may delay treatment with clozapine. Consequently, additional information is needed to understand fully the consequences of antipsychotic medications (desired and undesired) as they are currently used in real clinical settings.
Detailed electronic patient records provide an ideal source of data to investigate real world risks and benefits of prescribing practices. The South London and Maudsley NHS Foundation Trust (SLaM) provides comprehensive secondary mental healthcare to a population of approximately 1.2 million residents in four London boroughs (Lambeth, Southwark, Lewisham and Croydon). The Clinical Record Interactive Search (CRIS) system makes it possible for researchers to search and retrieve anonymised clinical records efficiently with over 250,000 cases represented in the CRIS system.
We are also able to link CRIS to general hospital data and cause of death data to provide information about physical health in mental health care service users. We are currently using CRIS to investigate the ways in which antipsychotics are used in clinical practice; what are the circumstances under which clinicians prescribe particular antipsychotics (or combinations of antipsychotics) and the impact that these prescribing practices have on the mental and physical health of service users.
Richard Hayes is funded by a Medical Research Council (MRC) Population Health Scientist Fellowship. The Clinical Records Interactive Search (CRIS) system is funded and developed by the National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London and a joint infrastructure grant from Guy’s and St Thomas’ Charity and the Maudsley Charity.
Tags: CRIS - Informatics - Clinical and population informatics -
By NIHR Maudsley BRC at 4 Jul 2016, 16:21 PM
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