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Archive
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2017
- January
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March
- Professor Robert Stewart awarded ‘Collaborate to Innovate’ project
- NIHR Maudsley BRC researchers receive Senior Investigator awards
- Research blog: Using social media to recognise mental health conditions
- Department of Health Chief Scientific Adviser Chris Whitty visits Maudsley BRC
- NIHR Maudsley BRC commences five-year research programme
- IMPARTS Seminar Learning from experience
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April
- New research highlights higher hospitalisation rates in people with intellectual disabilities
- Digital Technology for Mental Health: Asking the right questions
- NIHR Maudsley BRC holiday closure Easter 2017
- Maudsley becomes London’s Global Digital Exemplar
- CRIS blog: An online risk calculator to identify candidates for early intervention services
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July
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- Who are the NIHR? #WeAreNIHR
- Brain stimulation may improve cognitive performance in people with schizophrenia
- Risk for bipolar disorder associated with faster ageing
- Omega-3 fatty acids improve symptoms in children and adolescents with ADHD
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August
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November
- Professor Oliver Howes receives Royal College of Psychiatrists Award
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- Honorary Degree for Professor Dame Til Wykes
- Concentrated naloxone nasal spray as good as injection
- Professor Matthew Hotopf appointed Vice Dean
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2016
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March
- CRIS Blog: Serious Mental Illness and Pregnancy
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April
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May
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June
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July
- CRIS blog: Investigating the impact of antipsychotic medications used to treat people with serious mental illness
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September
- Matthew Hotopf wins prestigious Katon Research Award
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October
- BRC leaders receive academic promotions
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- Research blog: How fatty clues in the blood are improving our understanding of Alzheimer’s disease
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November
- South London and Maudsley rated top mental health trust for recruiting patients to clinical studies
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December
- Event Suicide detection and prevention using mobile technology, social media and informatics
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2018
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April
- UK Biobank mental health study
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November
- 2018 Takeover Challenge
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- CRIS blog: Do long-term prescriptions of multiple antipsychotics contribute to the reduced life expectancy of patients with serious mental illness?
- Improving dementia care and treatment saves thousands of pounds in care homes
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December
- Computers can ‘spot the difference’ between healthy brains and the brains of people with Dissociative Identity Disorder
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- New Clinical Disorders and Health Behaviours cluster lead announced
- Blog: The SLG Arts Assassins collaborate with the BRC
- Professor Matthew Hotopf receives CBE at Buckingham Palace
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2019
- January
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February
- Eating a healthy diet can ease symptoms of depression
- Pathfinders and the public
- NIHR Maudsley BRC researchers host dementia discussion in collaboration with South London Theatre
- Could intranasal oxytocin be used to treat people at clinically high risk of psychosis?
- CRIS blog: Using data on hospital episodes to look at the physical health of people with personality disorders
CRIS blog: Do long-term prescriptions of multiple antipsychotics contribute to the reduced life expectancy of patients with serious mental illness?
Dr Giouliana Kadra is a postdoctoral research associate at the Institute of Psychiatry, Psychology & Neuroscience at King’s College London.
It has been estimated that the life expectancy of patients with serious mental illnesses is 15 to 20 years shorter than that of the general population. The widespread use of treatment regimens not recommended by existing guidelines, such as antipsychotic polypharmacy (the simultaneous prescription of two or more antipsychotics drugs), has been suggested as a possible reason for this. Furthermore, this risk has been reported to increase with high dose prescriptions, especially when exceeding national recommendations.
Our study addresses a call for further research to examine the risk of death for patients who are prescribed a regular long-term use of two or more antipsychotic drugs simultaneously and to determine whether this polypharmacy-associated risk has any relationship with the cause of death and the antipsychotic dosage.
Using CRIS data (from a large anonymised mental healthcare database), we identified all adult patients with serious mental illness (SMI) who had been prescribed a single antipsychotic or polypharmacy, for six or more months between 2007 and 2014.
Our key findings were that we found a weak relationship between long-term antipsychotic polypharmacy (multiple drug use) and natural causes of death. However, we found no relationship between polypharmacy and unnatural causes of death. We also found no evidence that the level of antipsychotic dosage increased or decreased the risk of death in patients with serious mental illnesses.
Our findings suggest that the effect of long-term antipsychotic polypharmacy on death is not clear-cut. Future research should focus on examining specific antipsychotic combinations that are commonly prescribed and their effect on particular natural causes of death, such as cardiovascular death.
Furthermore, it is important to note that our research was focussed on the risk of death and the types of causes of death. Despite the lack of a strong relationship between antipsychotic polypharmacy and death, research continues to demonstrate a relationship between antipsychotic polypharmacy and more severe side-effects. So antipsychotic polypharmacy does come with risks, which do need to be taken into account and balanced against patient outcomes.
The full paper, ‘Long-term antipsychotic polypharmacy prescribing in secondary mental health care and the risk of mortality’, was published in Acta Psychiatrica Scandinavica. Read it online: doi.org/10.1111/acps.12906
Tags: CRIS blog -
By NIHR Maudsley BRC at 20 Nov 2018, 14:34 PM
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