Six years of memory decline seen in anxious, depressed older people during pandemic

Older people who were more anxious and depressed during the first year of the COVID-19 pandemic were found to have an average decline in their short term memory equivalent to six years of natural ageing.

The research was conducted by the PROTECT study, led by the University of Exeter and the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London, and funded by National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre. The study was presented yesterday at the Clinical Trials on Alzheimer’s Disease Conference. The team found that participants aged 50 and over who reported an increase in validated measures of anxiety and depression also scored lower on cognitive tasks designed to measure short term memory and attention. For memory, the decrease was the equivalent to the decline normally seen over six years of natural ageing. For attention, the difference was the equivalent of five years of ageing.

The PROTECT study is an online cohort of people aged 40 and over, who regularly provide lifestyle information in detailed questionnaires, and take part in cognitive tests. The unique study aims to help researchers understand what factors are involved in how the brain ages, and what can be done to keep our minds healthy in later life.

Researchers were able to use data from the PROTECT study collected over the last five years, and look at the impact of the pandemic peak of 2019-2020 in 6,300 people aged 50 and over (the minimum sign-up age at the time of the study).

Dr Helen Brooker, of the University of Exeter, led the research. She said: “We found that people who were more anxious and depressed during 2019-20 also saw their short term memory and ability to focus worsen, by the equivalent of five to six years of what we’d expect to see from natural ageing.  It’s likely that key factors were the unprecedented impact of worsening mental health caused by widespread anxiety over the pandemic, and long periods of lockdown. We need to understand this better so we can create effective strategies to support people and preserve both mental health and brain health in future pandemics.”

The study utilised measures of depression and anxiety severity commonly used in clinic. Researchers noted a significant shift in the number of people scoring higher on these scales than previously. Cognitive tests found the largest dip in memory and attention were seen in those whose scores would indicate moderate or higher levels of anxiety and depression.

Professor Dag Aarsland from King’s IoPPN said “Our innovative PROTECT study has enabled us to gain this valuable insight by working with participants over time. We had five years of mental health reports and online scores in brain tests, which has enabled us to pinpoint the impact of the pandemic. We will continue to monitor how this plays out over time, so our insights can help us fully understand the impact of this pandemic, to help us prepare for future events on the same scale.”

Dr Anne Corbett, of the University of Exeter, said: “The large number of people who take part in PROTECT and complete our tests and questionnaires are incredibly valuable to helping us understand what really matters in protecting our brain health. Anyone aged 40 or over can sign up to join us. Our research is conducted entirely online, and you would be making a valuable contribution to science.”

To sign up to PROTECT, visit

Tags: research stories - Covid-19 -

By NIHR Maudsley BRC at 9 Nov 2021, 09:40 AM

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