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- Fellows award for Dr Katherine Young for work on the mental health of young people during and after the pandemic
- NEWS2 evaluated for prediction of severe COVID-19 outcome in large international study
- SIREN study finds past COVID-19 infection provides some immunity for at least five months
- Interview with Miguel Vasconcelos Da Silva
- COVID-19 lockdown loneliness linked to more depressive symptoms in older adults
- The significant effect of lockdown on gambler’s mental health
- Antibiotic may improve outcomes for depression in people with low level inflammation
- Novavax trial reveals 89.3% effectiveness in preventing COVID-19
- Case studies
- Deciphering the genetics behind eating disorders
- NIHR appoints Senior Investigators for 2021
- Depression and anxiety are associated with disagreement between patient and doctor assessments of psoriasis severity.
- Professor Peter Goadsby awarded world’s top Brain Prize 2021
- Interview with Dr Parisa Mansoori
- New study highlights the urgent need to reduce inflammation in overweight people with depression
- Novavax confirms vaccine provides 100% protection against severe COVID-19
- NIHR welcomes new vision for the Future of UK Clinical Research Delivery
- COVID-19 pandemic leads to rapid uptake of remote consultations in mental healthcare
- An Interview with Chifundo Stubbs
- Brain scans could offer sign of postpartum psychosis risk
- Innovative UK data hub to enable research and innovation to tackle mental illness
- Inflammation is a core feature of depression: new evidence from large-scale study
- Mothers’ depression impacts mother-infant relationships
- Shifts to remote mental health services continued after lockdown, according to new study
- An interview with Zunera Khan
- Silent MRI: improving access to neuroimaging research
- Simple blood test can accurately reveal underlying neurodegeneration, according to new research
- New research from King's has identified three key inflammatory proteins which are lower in individuals at risk of severe COVID-19.
- New insight into how anti-inflammatory effects of omega-3 fatty acids could help reduce depression
- Five ways universities could improve mental health support for male students
- CogStack wins an Artificial Intelligence in Health and Care Award
- Volunteer calls for others to support dementia research in south London
- Europe's first 'game-changing' portable MRI machine arrives at King's Health Partners
- Global ALS/MND recognition Day
- Multiple long-term physical health problems increase risk of depression later in life
- An interview with Dr Marija-Magdalena Petrinovic
- COVID-19 variant vaccine begins recruiting in south London
- New Race and Ethnicity Advisory (READ) group is recruiting members
- NIHR Fellowship awarded to Dr Brendon Stubbs for research in persistent pain and serious mental illness
- Knowing what we don’t know: How statistics can help autistic people to live their best life
- BRC researchers on the Highly Cited list doubles to twenty
- CRIS Blog: Are we under-estimating self-harm rates due to differences in hospital admittance procedures?
- BRC Researchers celebrated at the King’s Awards
- New study finds evidence for reduced brain connections in schizophrenia
- Exposure to trauma ‘activates’ genes into causing depression
- Nurses in research blog: Emma and Naomi
- New findings on the effects of cannabidiol on people with psychosis
- New centre of excellence for children and young people's mental health launched
- High volumes of mental health-related tweets associated with crisis referrals
- Call opens to drive the future of health data research
- CRIS Blog: Answering real-world questions about medication and mental health through pharmacoepidemiology
- CRIS Blog: Appropriate use of healthcare records for research
- CRIS Blog: Artificial Intelligence and Data in Suicide Prevention
- Largest ever study of eating disorders launches in England
- C4C research register now totals 20,000 people
- Georgia’s research secondment
- Study finds that Community Treatment Orders do not reduce hospital readmission rates or stays
- 10,000 people could benefit from new migraine drug
- Thirty risk factors found during and after pregnancy for children developing psychosis
- Heroin injection associated with respiratory disorder
- Researchers appeal to public for help to assess mental health impact of the COVID-19 pandemic
- CRIS Blog: CRIS in the time of coronavirus
- Depression and anxiety increase premature death by up to 134%
- Mental health and brain research must be a higher priority in global response to tackle COVID-19 pandemic
- Stories from our students: Becki
- COPE Study: Investigating the impact of the COVID-19 pandemic on mental health and well-being
- Thought provoking men’s mental health film released
- Animated parenting tips for struggling households
- Researchers track COVID-19 isolation effects on older people’s health and wellbeing
- From Babylonian blood-letting practices to wearable tech, new film on the evolution of depression perceptions and treatment
- Patient and public recommendations for getting involved in BRC research
- Cognitive behavioural therapy reduces the impact of dissociative seizures
- Mind the Gap 17-25: A diagnosis doesn’t define you
- Sarah Markham writes about her experiences in research
- Covid-19 Psychiatry and Neurological Genetics (COPING) study
- Trial testing a unique formulation of ibuprofen to treat COVID-19 launches
- New study to monitor the real-time effect of COVID-19 on mental health services
- Introducing the CRIS Natural Language Processing (NLP) Service
- Study shows Cognitive Remediation Therapy leads to improvement in cognitive skills and well-being in people with bipolar disorder
- New Research Training and Capacity Development lead announced
- Growing numbers of alcohol related hospital admissions linked to local spending cuts
- ACE inhibitors and ARBs not associated with severity of Coronavirus
- Data linkages animation explores the evolution of healthcare records in research
- Study estimates impact of COVID-19 pandemic on UK mental health after first month of lockdown
- Genes related to inflammation and stress may help tailor treatments for depression
- Can wearables like Fitbit devices be used to help detect COVID-19?
- Lithium in drinking water linked with lower suicide rates
- Loss of potential: teens diagnosed with depression show reduction in educational achievement from primary school to GCSE
- £1.2 million to roll-out dementia care home programme to COVID-hit sector
- NIHR announces mental health research goals for next decade
- Rosalind helps researchers navigate personal health data
- An interview with Dr Ndaba Mazibuko
- National study into neurological impact of COVID-19
- Study supports link between traffic-related air pollution and mental disorders
- How our eLIXIR research database helps reduce risk of health problems in mothers and children
- Dr Helen Munn new chair of External Scientific Advisory Board
- An interview with Dr Anoushka Leslie
- 18 BRC Researchers Amongst Most Highly Cited in World
- Using patient data to understand service use and improve care during the COVID-19 pandemic
- Experts call for new consensus on Mild Cognitive Impairment (MCI)
- Eating a healthy diet can ease symptoms of depression
- CRIS Blog: Pathfinders and the public
- NIHR Maudsley BRC researchers host dementia discussion in collaboration with South London Theatre
- Could intranasal oxytocin be used to treat people at clinically high risk of psychosis?
- CRIS blog: Using data on hospital episodes to look at the physical health of people with personality disorders
- Cannabis-based medicine to be tested in Alzheimer's trial
- Largest ever study of depression and anxiety now recruiting individuals from Northern Ireland, Scotland, and Wales
- One in ten UK hospital inpatients is alcohol dependent
- CRIS Blog: Art and Value at Bethlem Gallery: an art-science collaboration with Sarah Carpenter and CRIS
- Genetic study reveals metabolic origins of anorexia
- Compensatory strategies to disguise autism spectrum disorder may delay diagnosis and have negative consequences for mental health
- Close monitoring essential to ensure safety of ketamine for depression
- Six BRC academics promoted to new positions, including two new professorships
- CRIS Blog: Medichec - A tool to make prescribing safer for people with dementia
- Study gets under way to test psilocybin for treatment-resistant depression
- 'An inspiring day': BRC community gathers to share knowledge at conference
- CRIS Blog: CRIS data demonstrates need for better physical healthcare for people who use heroin
- SURE Recovery: the new addiction recovery app designed alongside service users
- Our first ever artist residency to kick off with Afrobeat and Dub gig in South London
- Expert panel examines barriers faced by working class academics
- UK Biobank mental health study
- CRIS blog: Using CRIS to evaluate mental health diagnoses in routine national statistics
- Engaging in physical activity decreases people’s chance of developing depression
- Unprecedented study identifies 44 genetic risk factors for major depression
- New research: Hospitals often missing dementia despite prior diagnosis
- 2018 Takeover Challenge
- CRIS blog: The future of psychiatry research
- CRIS blog: Do long-term prescriptions of multiple antipsychotics contribute to the reduced life expectancy of patients with serious mental illness?
- Improving dementia care and treatment saves thousands of pounds in care homes
- New service in south London reduces hospital readmissions for people with bipolar disorder
- Ten BRC researchers and academics among most cited in the world
- Students 'take over' the BRC
- Computers can ‘spot the difference’ between healthy brains and the brains of people with Dissociative Identity Disorder
- Service User Advisory Group for 12-16-year-olds
- New Clinical Disorders and Health Behaviours cluster lead announced
- Blog: The SLG Arts Assassins collaborate with the BRC
- Professor Matthew Hotopf receives CBE at Buckingham Palace
- Professor Robert Stewart awarded ‘Collaborate to Innovate’ project
- NIHR Maudsley BRC researchers receive Senior Investigator awards
- Research blog: Using social media to recognise mental health conditions
- Department of Health Chief Scientific Adviser Chris Whitty visits Maudsley BRC
- NIHR Maudsley BRC commences five-year research programme
- IMPARTS Seminar Learning from experience
- New research highlights higher hospitalisation rates in people with intellectual disabilities
- Digital Technology for Mental Health: Asking the right questions
- Maudsley becomes London’s Global Digital Exemplar
- CRIS blog: An online risk calculator to identify candidates for early intervention services
- NIHR Maudsley BRC researcher wins award to understand suicide warning signs in children
- Who are the NIHR? #WeAreNIHR
- Brain stimulation may improve cognitive performance in people with schizophrenia
- Risk for bipolar disorder associated with faster ageing
- Omega-3 fatty acids improve symptoms in children and adolescents with ADHD
- South London and Maudsley tops NIHR league table for number of active research studies
- Connecting care homes with research
- Research blog: Using advanced search technologies to help manage infectious disease outbreaks
- A&E attendance for people with dementia is common and increasing
- Event: Seminar on dementia art project "Beyond Memories"
- Professor Oliver Howes receives Royal College of Psychiatrists Award
- First network analysis of patient flow in two UK hospitals published
- Honorary Degree for Professor Dame Til Wykes
- Concentrated naloxone nasal spray as good as injection
- Professor Matthew Hotopf appointed Vice Dean
- Potential for machine learning to predict unknown adverse drug reactions
- Complications at birth associated with lasting chemical changes in the brain
- Study examines opiate-dependent patient deaths
- NIHR Lectureship awarded
- Treatment cuts migraine days by half
- CRIS Blog: Serious Mental Illness and Pregnancy
- Kings world-class contribution to understanding of clozapine
- Research blog: PROMPT project reveals complex profile of people using psychological therapy services
- Tony David John Toulmin Lecture
- Crick synapse event
- IMPARTS Seminar Harnessing digital technology in mental and physical healthcare
- CRIS blog: Eight years on
- Experts call for greater recognition of little-known forms of dementia
- Event: Clinical Research Facility Research Forum
- Ewan Birney MRC SGDP Seminar
- Al Chalabi Sheila Essey Award
- Event Pint of Science 2016
- RADAR CNS smartphone wearable devices transform medical care
- Cardiovascular drug underprescribing
- Consultation reveals better integration between physical & mental health physicians as top priority
- Prestigious Fellowships awarded to BRC researchers
- Dermatology clinic psychology screening project shortlisted for BMJ Awards
- Independent Researcher Awards 2016
- BMJ Award for team who are incorporating mental health service into dermatology clinic
- Research blog systematic biases in death certification
- Event launch of new collaboration for digital innovation in mental health
- Victoria Derbyshire show inheritance mental illness
- BRC spin out Mindwave launches
- Research blog: Learning how to be a critical friend to researchers
- Research blog International Clinical Trials Day
- Blood test to personalise depression treatment for the first time
- Centre for Translational Informatics launches
- Professor John Strang receives Knighthood
- Film mental health summer school
- Mental health hackday - your help needed
- Research blog: Trialling an online tool to help women make decisions about antidepressants in pregnancy
- Data linkage group your help needed
- CRIS blog: Investigating the impact of antipsychotic medications used to treat people with serious mental illness
- Research blog Maudsley BRC part of winning team at NIHR training camp
- Neuroimaging theme research funding
- NIHR Maudsley BRC announces 2016 Youth Awards winners
- Event: Illusions A window to your brain
- Matthew Hotopf wins prestigious Katon Research Award
- IMPARTS shortlisted for HSJ award
- NIHR Maudsley BRC receives £66m new investment from government
- NIHR Maudsley BRC researchers win prestigious awards
- Event NIHR i4i Programme Mental Health Challenge Awards Launch
- Genetic tests could help predict which psychosis patients will develop schizophrenia
- BRC leaders receive academic promotions
- Event No Exchange, Same Pain, No Gain - Risk-Reward of Wearable Healthcare Disclosure for Receiving Pain Treatment
- C4C recruits 10k
- Research blog: How fatty clues in the blood are improving our understanding of Alzheimer’s disease
- Early intervention shows promising long-term reduction in severity of autism symptoms
- Bringing mental health education to a classroom of 300
- South London and Maudsley rated top mental health trust for recruiting patients to clinical studies
- Mental Health & Technology: Ideas Generation Workshop
- NIHR i4i mental health challenge launch
- UK Government announces £4m investment in NIHR Wellcome Trust King’s Clinical Research Facility
- NIHR Maudsley BRC PhD student wins International Society for the History of Neurosciences book prize
- NIHR Maudsley BRC's takeover challenge
- Event Suicide detection and prevention using mobile technology, social media and informatics
- Event Misconceptions and Reconceptualisations in Digital Mental Health
- Research blog: Defining treatment resistance in schizophrenia
- Mental health needs of baby boomers covered in new report from England’s Chief Medical Officer
An interview with Dr Marija-Magdalena Petrinovic
Dr Marija-Magdalena Petrinovic is our Translational Neuroscience Champion. The NIHR Maudsley BRC Research Champions, aim to promote innovation and advancement in areas of BRC strategic priority. Dr Petrinovic is currently a Lecturer in Forensic and Neurodevelopmental Sciences at the Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King’s College London (KCL).
Please can you give us an overview of your roles?
Within the BRC, my role is that of a Translational Neuroscience Champion. Scientists and policy makers are increasingly concerned that scientific discoveries are not translated effectively into tangible human benefit. This is mainly because of two main obstacles, or translational roadblocks. The first involves the transfer of new discoveries of disease mechanisms gained in the laboratory into the development of new methods for diagnosis, therapy, and prevention and their testing in humans. The second lies in translating clinical studies into everyday medical practices and health policies. These roadblocks can be removed only by the collaborative efforts of multiple stakeholders. Within the BRC, I work closely with other BRC members to develop BRC translational strategy by identifying opportunities for translation development, facilitating connections between different internal and external stakeholder groups and by organizing events and meetings to promote opportunities for collaboration between basic scientists and clinical researchers with access to relevant patient populations. I am currently preparing one such event.
As a Lecturer at the Department of Forensic and Neurodevelopmental Sciences, together with my team, I work on challenging behaviours that are associated with neurodevelopmental conditions, such as autism. Within that role, I am also a Module Lead at two different MSc programmes (MSc in Clinical Neurodevelopmental Sciences and MSc in Developmental Psychology and Psychopathology), and I teach neuroscience and research methods across several MSc programmes at the IoPPN.
In addition to my academic roles, I also serve as a Gender Equality Champion at the IoPPN, a departmental representative in the IoPPN Diversity and Inclusion Self-Assessment Team, a member of the IoPPN Research and Innovation Committee and as a member of the KCL Academic Board.
What is your favourite part of your BRC role?
I really enjoy working with colleagues from different BRC clusters and different research backgrounds. This provides lots of learning opportunities, as only by widening our research horizons we will be able to cross the bench-to-bedside gap and deliver the best treatments and care to patients. I like being the person who liaises between basic scientists and clinicians and who helps bring these “two worlds” closer together to enhance our translational efforts. I was very lucky to be part of translational neuroscience from the very beginning of my career, when I learnt that patient involvement is crucial for any successful translation. Patient involvement is an important part of the BRC and I really like hearing those first hand experiences as they are very helpful in steering and focusing our research efforts.
Can you give a brief overview of your career? What are you most proud of?
My deep interest and commitment to translational neuroscience started when, as a child during the war in Croatia, I witnessed the devastating consequences of spinal cord injuries. Many of these people faced a harsh verdict from their injury and a member of my family was amongst the large number of people wounded in this way. After realising that physicians were unable to offer much help because of the lack of knowledge as to why injured spinal neurons do not regenerate, I went on to study molecular biology at the University of Zagreb, Croatia. I then joined the lab of Professor Martin Schwab at the ETH Zürich , Switzerland, to study regeneration after spinal cord injury. It was here I worked on a molecule called Nogo-A, which is an inhibitor of regeneration and is now being tested in clinical trials. During that time, I was among the first to show that Nogo-A also plays an important role in nervous system development. By the end of my PhD, I had learned a lot about translational neuroscience, but I still lacked one important piece of knowledge – drug development. I decided to join the pharmaceutical company Roche, Switzerland, to learn how drug development and testing works, how to identify “druggable” targets and how to move compounds from preclinical to clinical phases.
After my postdoc, I returned to academia by starting my first independent post at the IoPPN. I was motivated by the opportunity to combine the research freedom of academia with my knowledge of drug development and testing, within an environment that is ideally suited for the translation of scientific findings into improving outcomes for individuals with neuropsychiatric and neurological disorders.
There are many things I am proud of because I had to overcome many obstacles during my career, but if I had to choose just one then it would be the growth of my team and students– I believe all our successes are results of our collaborative efforts.
As well as relying on teamwork, scientific research is inextricably dependent on teaching and I am also very proud of being nominated for and being awarded student-led King’s Education Awards. As, I am sure, every teacher will agree, teaching is not easy, but seeing one’s students growing scientifically, improving their knowledge and skills, and becoming independent is very rewarding. Each Christmas I get a bunch of cards from my former students from all over the world – and this is something I really appreciate. As scientists, we impact the world not just by our research, but even more by teaching and training the next generation of scientists.
How did you get interested in research?
My interest in science started in my early childhood while watching Sir David Attenborough’s documentaries and then discussing them with my dad. I still remember the excitement of seeing and learning about all those wonderful and exotic animals and how they adapt to their environments. One of my great wishes is to visit the Galápagos Islands which is the inspiration of Darwin’s theory of evolution. From this initial awe with the natural world, my interest in neuroscience was born – as all our behaviours, thoughts, feelings, hopes and dreams originate in our brain.
How has the Covid-19 pandemic affected your work / life?
The current Covid-19 pandemic is having a huge effect on everyone; balancing personal life whilst developing and implementing transformative measures aimed at sustaining teaching and research activity from home was very challenging. I moved into my lab space in 2019 and our research was moving full throttle when the pandemic brought us to a standstill. During that time, my team was engaged in minimal on-campus research efforts based on what can be done whilst adhering to social distancing. In the meantime, we have been analysing previously acquired data and have prepared several papers. We are looking forward to getting back into the lab and having face-to-face meetings as Teams and Zoom lab meetings are no substitute for the spontaneous interactions that spark new ideas.
On the other hand, this pandemic has also opened new opportunities and many things that we have previously thought impossible, are now becoming normal and in some cases even a mainstay. For example, online teaching has been shown to be on a par, if not even better than face-to-face teaching, offering greater opportunities and more personalised learning experiences to our students. Although productivity for many researchers was understandably lower during the pandemic, having time to think, focus and reflect on previous practices brings higher quality outcomes and greater job satisfaction and better productivity in the long run. Few will contemplate a complete return to how we worked and operated before.
What does an average working day look like for you?
This is quite difficult to say as every day or week is different and I really like that variety about my job. In each week I need to juggle classroom and lab teaching, lab work, writing up manuscripts and funding proposals, marking students’ essays and exams, reading papers to stay on top of my field, group meetings to discuss current and future projects, alongside meetings related to the work of various boards and committees of which I am a member. This means careful time management, but there must always be some room for ad hoc changes and for meeting my students for whom my doors – virtual or otherwise - are always open.
What are you working on at the moment?
My group is working on aggression and irritability associated with neurodevelopmental conditions. Aggression and related challenging behaviours such as irritability, impulsivity and intermittent explosivity are common comorbid presentations in autism, ADHD, schizophrenia and psychopathy and they have a serious negative impact on both affected individuals and their families. These challenging behaviours often result in social isolation, caregiver burnout, removal from education-based settings and entry into the criminal justice system - yet we lack effective treatments. Given the worldwide increase in the incidence of neurodevelopmental conditions, development of effective interventions is urgently needed. However, the search for therapies is hampered by our poor understanding of causal neurobiological mechanisms.
In order to identify those neurobiological mechanisms, we are integrating both preclinical (e.g. animal models) and clinical research. Such a translational approach helps to bridge the gap between basic and clinical research and holds promise to rapidly impact upon our understanding and treatment of challenging behaviours associated with neurodevelopmental conditions.
All about you
Favourite book / TV series / box set of 2020
It is quite difficult to pick one book, as so many of them have a special meaning for me and/or have impacted my life. Since my school days I enjoy reading (and re-reading) Shakespeare, Oscar Wilde and Molière. During the last couple of years, I have been recommending to my friends Jared Diamond’s Guns, Germs, and Steel: The Fates of Human Societies, The Shadow of the Wind by Carlos Ruiz Zafón, and The Century Trilogy by Ken Follett (Fall of Giants, Winter of the World and Edge of Eternity).
Unlike choosing a favourite book, deciding about my favourite TV programme is easy – Sir David Attenborough’s documentaries.
What is your go-to karaoke song?
I must admit that I give karaoke a wide berth - but it would probably be something by Barbra Streisand or Tina Turner.
How would you spend your perfect Saturday?
At a seaside – walking, swimming, and brunch with friends and family.
Best discovery of lockdown 1, 2 or 3?
I have discovered some wonderful local parks and coffee shops and have finally started taking guitar lessons. However, one of the most important discoveries - reminders actually - was about our resilience, adaptability and importance of science in our societies.
Tags: BRC Interview Series - Staff News -
By NIHR Maudsley BRC at 2 Jul 2021, 13:46 PM
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